Zhi-Gang Xiong Selected Research

Acidosis

1/2022	pH and proton-sensitive receptors in brain ischemia.
12/2020	GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia.
11/2020	Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway.
10/2019	β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation.
5/2019	Acute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity.
2/2017	Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury.
1/2016	Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke.
2/2012	Physiological and pathological functions of acid-sensing ion channels in the central nervous system.
2/2011	Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
10/2010	Developmental change in the electrophysiological and pharmacological properties of acid-sensing ion channels in CNS neurons.

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Zhi-Gang Xiong Research Topics

Disease

22	Acidosis 01/2022 - 07/2003
12	Brain Ischemia (Cerebral Ischemia) 01/2022 - 12/2003
11	Brain Injuries (Brain Injury) 10/2019 - 06/2004
11	Stroke (Strokes) 10/2019 - 09/2004
9	Ischemia 12/2020 - 06/2004
6	Ischemic Stroke 05/2019 - 01/2011
5	Infarction (Infarctions) 01/2016 - 01/2007
4	Pathologic Processes 02/2015 - 01/2007
3	Neoplasms (Cancer) 01/2017 - 01/2011
2	Hyperglycemia 01/2018 - 01/2013
2	Nervous System Diseases (Neurological Disorders) 01/2016 - 02/2012
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2016 - 01/2007
2	Traumatic Brain Injuries (Traumatic Brain Injury) 02/2012 - 01/2011
2	Seizures (Absence Seizure) 02/2012 - 01/2011
2	Epilepsy (Aura) 01/2011 - 12/2010
2	Asthma (Bronchial Asthma) 01/2011 - 07/2008
2	Inflammation (Inflammations) 01/2011 - 01/2011
2	Rhinosinusitis 06/2009 - 07/2008
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/2008 - 11/2007
1	Neuroinflammatory Diseases 01/2022
1	Ovarian Neoplasms (Ovarian Cancer) 01/2022
1	Wounds and Injuries (Trauma) 12/2020
1	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2019
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019
1	Hypertension (High Blood Pressure) 01/2016
1	Alkalosis 01/2016
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2016
1	Infections 12/2015
1	Noncommunicable Diseases 12/2015
1	Chlamydia Infections 12/2015
1	Glioma (Gliomas) 02/2012
1	Multiple Sclerosis 02/2012
1	Disseminated Intravascular Coagulation 01/2011
1	Status Epilepticus (Complex Partial Status Epilepticus) 01/2011
1	Pancreatitis 01/2011

Drug/Important Bio-Agent (IBA)

17	Acid Sensing Ion ChannelsIBA 11/2020 - 09/2004
10	Protons (Proton)IBA 01/2022 - 01/2007
9	Proteins (Proteins, Gene)FDA Link 11/2020 - 06/2004
6	CationsIBA 02/2015 - 07/2003
5	AcidsIBA 01/2022 - 09/2006
5	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2016 - 02/2006
5	Ion Channels (Ion Channel)IBA 02/2012 - 01/2007
4	Glutamate Receptors (Glutamate Receptor)IBA 04/2014 - 09/2004
4	Glutamic Acid (Glutamate)FDA Link 02/2014 - 09/2004
4	CalciumIBA 02/2014 - 07/2003
3	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 01/2013
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2022 - 12/2020
2	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2019 - 04/2014
2	Long Noncoding RNAIBA 01/2019 - 01/2017
2	N-Methylaspartate (NMDA)IBA 01/2016 - 01/2008
2	Phosphotransferases (Kinase)IBA 01/2016 - 02/2015
2	NeuropeptidesIBA 01/2011 - 06/2004
2	EnzymesIBA 07/2008 - 06/2004
2	Carboxypeptidase H (Carboxypeptidase E)IBA 01/2008 - 06/2004
1	Protein Kinase CIBA 12/2020
1	ProteomeIBA 01/2020
1	Estradiol (Delestrogen)FDA LinkGeneric 10/2019
1	Neuroprotective AgentsIBA 05/2019
1	Sirolimus (Rapamycin)FDA Link 05/2019
1	Ethanol (Ethyl Alcohol)IBA 05/2019
1	Fibrinolytic Agents (Antithrombotic Agents)IBA 01/2019
1	MicroRNAs (MicroRNA)IBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	Antisense RNA (Anti-Sense RNA)IBA 01/2017
1	Quinine (Quinson)FDA Link 01/2016
1	GlucocorticoidsIBA 01/2016
1	Biological ProductsIBA 01/2016
1	benzamilIBA 01/2016
1	Amiloride (Midamor)FDA LinkGeneric 01/2016
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2016
1	Oxygen (Dioxygen)IBA 01/2016
1	EMD 638683IBA 01/2016
1	2- cyclopentyl- 4- (5- phenyl- 1H- pyrrolo(2,3- b)pyridin- 3- yl)- benzoic acidIBA 01/2016
1	PropionatesIBA 01/2016
1	ethylisopropylamiloride (EIPA)IBA 01/2016
1	VaccinesIBA 12/2015
1	Interleukin-10 (Interleukin 10)IBA 12/2015
1	InflammasomesIBA 12/2015
1	LigandsIBA 11/2015
1	Neostigmine (Neostigmine Bromide)IBA 11/2012
1	Cholinergic ReceptorsIBA 11/2012
1	Acetylcholine (Acetylcholine Chloride)FDA Link 11/2012
1	Retinaldehyde (Retinal)IBA 02/2012
1	Lactic Acid (Lactate)FDA LinkGeneric 02/2012
1	SpermineIBA 02/2011
1	PolyaminesIBA 02/2011
1	gamma-Aminobutyric Acid (GABA)IBA 01/2011
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2011
1	GABA-A Receptors (GABA(A) Receptor)IBA 01/2011
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2011
1	Dacarbazine (DIC)FDA LinkGeneric 01/2011
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2011
1	Type I Tumor Necrosis Factor ReceptorsIBA 01/2011
1	CytokinesIBA 01/2011
1	Degenerin Sodium ChannelsIBA 01/2011
1	Divalent CationsIBA 12/2010

Therapy/Procedure

5	Therapeutics 04/2014 - 12/2003
1	Sutures (Suture) 10/2019
1	Thrombectomy 01/2019
1	Stents 01/2019